COVID-19 Evidence Alerts
from McMaster PLUSTM

Current best evidence for clinical care (more info)

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Diagnosis Ciccarese F, Coppola F, Spinelli D, et al. Diagnostic Accuracy of North America Expert Consensus Statement on Reporting CT Findings in Patients Suspected of Having COVID-19 Infection: An Italian Single-Center Experience. Radiol Cardiothorac Imaging. 2020 Jul 23;2(4):e200312. doi: 10.1148/ryct.2020200312. eCollection 2020 Aug.
Abstract

Purpose: To evaluate the diagnostic accuracy of the four standardized categories for CT reporting proposed by the Radiological Society of North America (RSNA) to support a faster triage compared with real-time reverse-transcription polymerase chain reaction (RT-PCR), which is the reference standard for suspected coronavirus disease 2019 (COVID-19), but has long reporting time (6-48 hours).

Materials and Methods: A retrospective analysis of 569 thin-section CT examinations performed for patients suspected of having COVID-19 from February 27 to March 27, 2020 (peak of infection in Italy) was conducted. The imaging pattern was classified according to the statement by the RSNA as "typical," "indeterminate," "atypical," and "negative" and compared with RT-PCR for 460 patients. Interobserver variability in reporting between a senior and a junior radiologist was evaluated. Use of the vascular enlargement sign in indeterminate cases was also assessed.

Results: The diagnosis of COVID-19 was made in 45.9% (211/460) of patients. The "typical" pattern (n = 172) showed a sensitivity of 71.6%, a specificity of 91.6%, and a positive predictive value of 87.8% for COVID-19. The "atypical" (n = 67) and "negative" (n = 123) pattern demonstrated a positive predictive value of 89.6% and 86.2% for non-COVID-19, respectively. The "indeterminate" (n = 98) pattern was nonspecific, but vascular enlargement was most frequently found in patients with COVID-19 (86.1%; P < .001). Interobserver agreement was good for the "typical" and "negative" pattern and fair for "indeterminate" and "atypical" (? = 0.5; P = .002).

Conclusion: In an epidemic setting, the application of the four categories proposed by the RSNA provides a standardized diagnostic hypothesis, strongly linked to the RT-PCR results for the "typical," "atypical," and "negative" pattern. In the "indeterminate" pattern, the analysis of the vascular enlargement sign could facilitate the interpretation of imaging features.© RSNA, 2020.

Ratings
Discipline / Specialty Area Score
Respirology/Pulmonology
Hospital Doctor/Hospitalists
Internal Medicine
Infectious Disease
Emergency Medicine
Comments from MORE raters

Emergency Medicine rater

I'm not sure how widespread these diagnostic criteria are. I certainly don't think any of us know how accurate they are.

Hospital Doctor/Hospitalists rater

The intent of this study was to address a potentially important clinical issue; namely whether criteria based on chest CT findings could be used in identify correctly patients with COVID-19 infections. The gold standard is the PCR confirmation of COVID-19. The first problem with the study, 109 out of 569 patients with CT studies for COVID-19 did not receive the PCR confirmation. The authors need to provide evidence that the failure to have PCR was not influenced by the CT findings; the opposite seems very plausible. Second, they report mostly positive predictive values, and these are entirely dependent on the disease prevalence; as they actually proved with figure 7. These potential significant flaws makes their reported findings uncertain and their interpretation fragile. These problems prompted this reviewer to rate the relevance lower and the importance of the findings significantly lower.

Respirology/Pulmonology rater

This is useful information to be confirmed by a multicentric study.