Risk factors for death in 1859 subjects with COVID-19

Leukemia. 2020 Aug;34(8):2173-2183. doi: 10.1038/s41375-020-0911-0. Epub 2020 Jun 16.

Abstract

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log10 neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log10 D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log10 serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log10NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Betacoronavirus / isolation & purification*
  • Biomarkers / blood*
  • COVID-19
  • Coronavirus Infections / blood
  • Coronavirus Infections / mortality*
  • Coronavirus Infections / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphocytes / pathology*
  • Male
  • Middle Aged
  • Mortality / trends*
  • Neutrophils / pathology*
  • Pandemics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / mortality*
  • Pneumonia, Viral / pathology
  • Prognosis
  • ROC Curve
  • Risk Factors
  • SARS-CoV-2
  • Severity of Illness Index*
  • Survival Rate

Substances

  • Biomarkers