Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis

SN Compr Clin Med. 2020;2(11):2126-2130. doi: 10.1007/s42399-020-00510-x. Epub 2020 Sep 10.

Abstract

With many drugs being tried in the management and treatment of COVID-19, dupilumab is one such monoclonal antibody that has come under the limelight for its possible role as an adjunct therapy in COVID-19 position. There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. There is also an ongoing debate regarding the continuation of biologicals in the COVID patient. In this article, a non-systematic critical analysis of dupilumab was performed to delve into this hypothesis further.

Keywords: Atopic dermatitis; COVID-19; Chronic rhino-sinusitis with nasal polyp; Dupilumab; Monoclonal antibody.