Therapeutic uncertainties in people with cardiometabolic diseases and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19)

Diabetes Obes Metab. 2020 Oct;22(10):1942-1945. doi: 10.1111/dom.14062. Epub 2020 May 19.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) has been declared a pandemic by the World Health Organization and sent all countries scrambling to review emergency healthcare provisions. There is global evidence of each nation struggling to effectively manage the number of people being diagnosed with the virus. These are testing times which have not been experienced in recent generations and there are a number of insecurities regarding the management of people with COVID-19 and cardiometabolic diseases. This review highlights the current concerns related to COVID-19 and provides advice in terms of the therapeutic uncertainty and potential adverse harms associated with therapy when managing people, particularly those with cardiometabolic diseases, who have contracted or are at increased risk of contracting COVID-19.

Keywords: type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • COVID-19 / complications*
  • COVID-19 / epidemiology
  • COVID-19 / therapy*
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / therapy*
  • Chloroquine / therapeutic use
  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / standards
  • Delivery of Health Care / methods
  • Delivery of Health Care / standards
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Metabolic Diseases / complications
  • Metabolic Diseases / epidemiology
  • Metabolic Diseases / therapy*
  • Middle Aged
  • Pandemics
  • SARS-CoV-2 / physiology
  • Uncertainty*

Substances

  • Glucocorticoids
  • Hypoglycemic Agents
  • Hydroxychloroquine
  • Chloroquine