Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score

Thorax. 2021 Sep;76(9):920-929. doi: 10.1136/thoraxjnl-2020-216001. Epub 2021 Feb 25.

Abstract

Objective: To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.

Design: Multivariable prognostic prediction model.

Setting: 127 Spanish hospitals.

Participants: Derivation (DC) and external validation (VC) cohorts were obtained from multicentre and single-centre databases, including 4035 and 2126 patients with confirmed COVID-19, respectively.

Interventions: Prognostic variables were identified using multivariable logistic regression.

Main outcome measures: 30-day mortality.

Results: Patients' characteristics in the DC and VC were median age 70 and 61 years, male sex 61.0% and 47.9%, median time from onset of symptoms to admission 5 and 8 days, and 30-day mortality 26.6% and 15.5%, respectively. Age, low age-adjusted saturation of oxygen, neutrophil-to-lymphocyte ratio, estimated glomerular filtration rate by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, dyspnoea and sex were the strongest predictors of mortality. Calibration and discrimination were satisfactory with an area under the receiver operating characteristic curve with a 95% CI for prediction of 30-day mortality of 0.822 (0.806-0.837) in the DC and 0.845 (0.819-0.870) in the VC. A simplified score system ranging from 0 to 30 to predict 30-day mortality was also developed. The risk was considered to be low with 0-2 points (0%-2.1%), moderate with 3-5 (4.7%-6.3%), high with 6-8 (10.6%-19.5%) and very high with 9-30 (27.7%-100%).

Conclusions: A simple prediction score, based on readily available clinical and laboratory data, provides a useful tool to predict 30-day mortality probability with a high degree of accuracy among hospitalised patients with COVID-19.

Keywords: clinical epidemiology; critical care; emergency medicine; pneumonia; respiratory infection; viral infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • COVID-19 / complications
  • COVID-19 / mortality*
  • Dyspnea / etiology
  • Dyspnea / virology
  • Female
  • Glomerular Filtration Rate
  • Hospital Mortality*
  • Humans
  • Inpatients / statistics & numerical data*
  • Logistic Models*
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Neutrophils
  • Oxygen / blood
  • ROC Curve
  • Risk Factors
  • SARS-CoV-2
  • Sex Factors

Substances

  • Oxygen