Chest CT in COVID-19 at the ED: Validation of the COVID-19 Reporting and Data System (CO-RADS) and CT Severity Score: A Prospective, Multicenter, Observational Study

Chest. 2021 Mar;159(3):1126-1135. doi: 10.1016/j.chest.2020.11.026. Epub 2020 Nov 30.

Abstract

Background: CT is thought to play a key role in coronavirus disease 2019 (COVID-19) diagnostic workup. The possibility of comparing data across different settings depends on the systematic and reproducible manner in which the scans are analyzed and reported. The COVID-19 Reporting and Data System (CO-RADS) and the corresponding CT severity score (CTSS) introduced by the Radiological Society of the Netherlands (NVvR) attempt to do so. However, this system has not been externally validated.

Research question: We aimed to prospectively validate the CO-RADS as a COVID-19 diagnostic tool at the ED and to evaluate whether the CTSS is associated with prognosis.

Study design and methods: We conducted a prospective, observational study in two tertiary centers in The Netherlands, between March 19 and May 28, 2020. We consecutively included 741 adult patients at the ED with suspected COVID-19, who received a chest CT and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR (PCR). Diagnostic accuracy measures were calculated for CO-RADS, using PCR as reference. Logistic regression was performed for CTSS in relation to hospital admission, ICU admission, and 30-day mortality.

Results: Seven hundred forty-one patients were included. We found an area under the curve (AUC) of 0.91 (CI, 0.89-0.94) for CO-RADS using PCR as reference. The optimal CO-RADS cutoff was 4, with a sensitivity of 89.4% (CI, 84.7-93.0) and specificity of 87.2% (CI, 83.9-89.9). We found a significant association between CTSS and hospital admission, ICU admission, and 30-day mortality; adjusted ORs per point increase in CTSS were 1.19 (CI, 1.09-1.28), 1.23 (1.15-1.32), 1.14 (1.07-1.22), respectively. Intraclass correlation coefficients for CO-RADS and CTSS were 0.94 (0.91-0.96) and 0.82 (0.70-0.90).

Interpretation: Our findings support the use of CO-RADS and CTSS in triage, diagnosis, and management decisions for patients presenting with possible COVID-19 at the ED.

Keywords: COVID-19; CT; emergency medicine; pneumonia.

Publication types

  • Multicenter Study
  • Observational Study
  • Validation Study

MeSH terms

  • COVID-19* / diagnosis
  • COVID-19* / epidemiology
  • Clinical Decision-Making
  • Emergency Service, Hospital / statistics & numerical data*
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mortality
  • Netherlands / epidemiology
  • Patient Admission / statistics & numerical data*
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / etiology
  • Prognosis
  • Radiology Information Systems* / organization & administration
  • Radiology Information Systems* / standards
  • Research Design / statistics & numerical data
  • SARS-CoV-2
  • Severity of Illness Index
  • Tomography, X-Ray Computed* / methods
  • Tomography, X-Ray Computed* / statistics & numerical data