Treatment of SARS-CoV-2 pneumonia with favipiravir: early results from the Ege University cohort, Turkey

Turk J Med Sci. 2021 Jun 28;51(3):912-920. doi: 10.3906/sag-2008-33.

Abstract

Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia.

Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia.

Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) when this paper was written.

Conclusion: This study provides relevant information for the treatment of COVID-19, suggesting that favipiravir was associated with significant clinical and laboratory improvements in the majority of the patients, is a safe drug with no serious side effects and would merit further investigation.

Keywords: antiviral therapy; coronavirus; favipiravir; pandemic; SARS-CoV-2; COVID-19; antiviral therapy.

MeSH terms

  • Adult
  • Aged
  • Amides / therapeutic use*
  • Antiviral Agents / therapeutic use
  • COVID-19 / epidemiology
  • COVID-19 Drug Treatment*
  • Female
  • Follow-Up Studies
  • Humans
  • Intensive Care Units / statistics & numerical data*
  • Male
  • Middle Aged
  • Pandemics*
  • Pyrazines / therapeutic use*
  • Retrospective Studies
  • SARS-CoV-2*
  • Time Factors
  • Treatment Outcome
  • Turkey / epidemiology

Substances

  • Amides
  • Antiviral Agents
  • Pyrazines
  • favipiravir