COVID-19 Evidence Alerts
from McMaster PLUSTM

Current best evidence for clinical care (more info)

Register to receive email alerts

COVID-19 Evidence Alerts needs your support. If our service is of value to you, please consider giving to keep it going. Learn more Give now

Search results

# Article
Higher quality Treatment Efficacy of COVID-19 Treatments: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.
Zhang C, Jin H, Wen YF, et al.
Front Public Health
Reviewed: Oct 22
34650951
Higher quality Treatment Efficacy and safety of ivermectin for the treatment of COVID-19: A systematic review and meta-analysis.
Deng J, Zhou F, Ali S, et al.
QJM
Reviewed: Oct 15
34570241
Higher quality Primary Prevention Pharmacological interventions to prevent Covid-19 disease: A rapid review.
Cardwell K, O Murchu E, Byrne P, et al.
Rev Med Virol
Reviewed: Oct 14
34582072
Higher quality Treatment Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: an updated network meta-analysis of randomized placebo-controlled trials.
Cheng Q, Chen J, Jia Q, et al.
Aging (Albany NY)
Reviewed: Sep 25
34531332
Higher quality Treatment Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Roman YM, Burela PA, Pasupuleti V, et al.
Clin Infect Dis
Reviewed: Aug 18
34181716
Higher quality Treatment, Primary Prevention Ivermectin for preventing and treating COVID-19.
Popp M, Stegemann M, Metzendorf MI, et al.
Cochrane Database Syst Rev
Reviewed: Aug 10
34318930
Higher quality Treatment Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial.
Vallejos J, Zoni R, Bangher M, et al.
BMC Infect Dis
Reviewed: Jul 21
34215210
Higher quality Treatment Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials.
Zein AFMZ, Sulistiyana CS, Raffaelo WM, et al.
Diabetes Metab Syndr
Reviewed: Jul 16
34237554
Higher quality Treatment Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon.
Samaha AA, Mouawia H, Fawaz M, et al.
Viruses
Reviewed: Jul 14
34073401
Higher quality Treatment Clinical Study Evaluating the Efficacy of Ivermectin in COVID-19 Treatment: A Randomized Controlled Study.
Abd-Elsalam S, Noor RA, Badawi R, et al.
J Med Virol
Reviewed: Jul 01
34076901
Higher quality Treatment Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial.
Mahmud R, Rahman MM, Alam I, et al.
J Int Med Res
Reviewed: May 22
33983065
Higher quality Primary Prevention Prophylaxis against covid-19: living systematic review and network meta-analysis.
Bartoszko JJ, Siemieniuk RAC, Kum E, et al.
BMJ
Reviewed: May 06
33903131
Higher quality Treatment Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review.
Bhowmick S, Dang A, Vallish BN, et al.
Drug Saf
Reviewed: Apr 26
33864232
Higher quality Treatment Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
Lopez-Medina E, Lopez P, Hurtado IC, et al.
JAMA
Reviewed: Mar 12
33662102
Higher quality Treatment Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis.
Padhy BM, Mohanty RR, Das S, et al.
J Pharm Pharm Sci
Reviewed: Feb 02
33227231
Under review Manuscript Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos.
Babalola OE, Bode CO, Ajayi AA, et al.
QJM
Reviewed: Nov 23
33599247
Does not meet our criteria Evidence Based Guideline ESCMID COVID-19 Living guidelines: drug treatment and clinical management.
Bartoletti M, Azap O, Barac A, et al.
Clin Microbiol Infect
Reviewed: Nov 26
34823008
Does not meet our criteria Review Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-Analysis.
Cruciani M, Pati I, Masiello F, et al.
Diagnostics (Basel)
Reviewed: Sep 28
34573986
Does not meet our criteria Primary Prevention Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study.
Morgenstern J, Redondo JN, Olavarria A, et al.
Cureus
Reviewed: Sep 14
34513523
Does not meet our criteria Primary Prevention Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers.
Behera P, Patro BK, Padhy BM, et al.
Cureus
Reviewed: Sep 14
34513470
Does not meet our criteria Review Role of ivermectin in patients hospitalized with COVID-19: a systematic review of literature.
Chaudhry MW, Zubair SM, Zubairi ABS, et al.
Adv Respir Med
Reviewed: Sep 09
34494244
Does not meet our criteria Treatment Self-prescribed Ivermectin use is associated with a lower rate of seroconversion in health care workers diagnosed with COVID, in a dose-dependent response.
Pedroso C, Vaz S, Netto EM, et al.
Braz J Infect Dis
Reviewed: Aug 16
34390646
Does not meet our criteria Review Pharmacological Treatment of Patients with Mild to Moderate COVID-19: A Comprehensive Review.
Bestetti RB, Furlan-Daniel R, Silva VMR
Int J Environ Res Public Health
Reviewed: Jul 20
34281149
Does not meet our criteria Treatment Evaluation of Ivermectin as a Potential Treatment for Mild to Moderate COVID-19: A Double-Blind Randomized Placebo Controlled Trial in Eastern India.
Ravikirti, Roy R, Pattadar C, et al.
J Pharm Pharm Sci
Reviewed: Jul 16
34265236
Does not meet our criteria Treatment Early COVID-19 Therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in Outpatient Settings Significantly Improved COVID-19 outcomes compared to Known outcomes in untreated patients.
Cadegiani FA, Goren A, Wambier CG, et al.
New Microbes New Infect
Reviewed: Jul 12
34249367
Does not meet our criteria Evidence Based Guideline Key summary of German national treatment guidance for hospitalized COVID-19 patients Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021).
Malin JJ, Spinner CD, Janssens U, et al.
Infection
Reviewed: Jul 07
34228347
Does not meet our criteria Review The antiviral activity of iota-, kappa-, and lambda-carrageenan against COVID-19: A critical review.
Frediansyah A
Clin Epidemiol Glob Health
Reviewed: Jul 06
34222718
Does not meet our criteria Treatment Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial.
Krolewiecki A, Lifschitz A, Moragas M, et al.
EClinicalMedicine
Reviewed: Jul 02
34189446
Does not meet our criteria Treatment Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.
Okumus N, Demirturk N, Cetinkaya RA, et al.
BMC Infect Dis
Reviewed: May 06
33947344
Does not meet our criteria Evidence Based Guideline Guidelines for clinical management of SARS-CoV-2 infection.
Garcia-Alvarez JL, Garcia-Vigil JL
Gac Med Mex
Reviewed: Apr 28
33877121
Does not meet our criteria Treatment Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial.
Seet RCS, Quek AML, Ooi DSQ, et al.
Int J Infect Dis
Reviewed: Apr 20
33864917
Does not meet our criteria Review Drugs intervention study in COVID-19 management.
Taher M, Tik N, Susanti D
Drug Metab Pers Ther
Reviewed: Apr 08
33818031
Does not meet our criteria Treatment Effect of a combination of Nitazoxanide, Ribavirin and Ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-19.
Elalfy H, Besheer T, El-Mesery A, et al.
J Med Virol
Reviewed: Feb 17
33590901
Does not meet our criteria Treatment Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study.
Behera P, Patro BK, Singh AK, et al.
PLoS One
Reviewed: Feb 17
33592050
Does not meet our criteria Treatment The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial.
Chaccour C, Casellas A, Blanco-Di Matteo A, et al.
EClinicalMedicine
Reviewed: Jan 27
33495752
Does not meet our criteria Review A narrative review of pharmacologic treatments for COVID-19: safety considerations and ototoxicity.
Little C, Cosetti MK
Laryngoscope
Reviewed: Jan 26
33491234
Does not meet our criteria Review From Hydroxychloroquine to Ivermectin: what are the anti-viral properties of anti-parasitic drugs to combat SARS-CoV-2?
Rakedzon S, Neuberger A, Domb AJ, et al.
J Travel Med
Reviewed: Jan 23
33480414
Does not meet our criteria Review Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis.
Kim MS, An MH, Kim WJ, et al.
PLoS Med
Reviewed: Dec 31
33378357
Does not meet our criteria Treatment A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness.
Ahmed S, Karim MM, Ross AG, et al.
Int J Infect Dis
Reviewed: Dec 21
33278625
Does not meet our criteria Treatment Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.
Camprubi D, Almuedo-Riera A, Marti-Soler H, et al.
PLoS One
Reviewed: Nov 13
33175880
Does not meet our criteria Treatment Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID-19 (ICON study).
Rajter JC, Sherman MS, Fatteh N, et al.
Chest
Reviewed: Oct 22
33065103
Not a category we appraise Review Self-medication practices to prevent or manage COVID-19: A systematic review.
Quincho-Lopez A, Benites-Ibarra CA, Hilario-Gomez MM, et al.
PLoS One
Reviewed: Nov 03
34727126
Not a category we appraise Corrigendum to Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial [EClinicalMedicine 37 (2021) 100,959]".
Krolewiecki A, Lifschitz A, Moragas M, et al.
EClinicalMedicine
Reviewed: Sep 01
34462733
Not a category we appraise Erratum: Expression of Concern: "Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection".
Hill A, Garratt A, Levi J, et al.
Open Forum Infect Dis
Reviewed: Aug 20
34410284