Risk of venous thromboembolism in pregnant women with essential thrombocythemia: a systematic review and meta-analysis

Blood. 2017 Feb 23;129(8):934-939. doi: 10.1182/blood-2016-09-728006. Epub 2017 Jan 3.

Abstract

We performed a meta-analysis to evaluate the risk of venous thromboembolism (VTE) in pregnant women with essential thrombocythemia. Twenty-one trials and 756 pregnancies met inclusion criteria. The absolute VTE risk in the antepartum period is not above a threshold where low-molecular-weight heparin (LMWH) prophylaxis is clearly indicated or below a threshold where LMWH should be withheld (2.5%; 95% CI, 1.3-4.3). Postpartum, the absolute VTE risk is above a threshold where postpartum LMWH prophylaxis should be considered (4.4%; 95% CI, 1.2-9.5).

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Anticoagulants / therapeutic use*
  • Female
  • Heparin, Low-Molecular-Weight / therapeutic use*
  • Humans
  • Postpartum Period / drug effects
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / etiology*
  • Pregnancy Complications, Cardiovascular / prevention & control*
  • Risk
  • Thrombocythemia, Essential / complications*
  • Venous Thromboembolism / etiology*
  • Venous Thromboembolism / prevention & control*

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight