Cardiovascular Complications of Pregnancy-Associated COVID-19 Infections

JACC Adv. 2022 Aug;1(3):100057. doi: 10.1016/j.jacadv.2022.100057. Epub 2022 Aug 10.

Abstract

Cardiovascular complications are frequently present in coronavirus-2019 (COVID-19) infection. These include microvascular and macrovascular thrombotic complications such as arterial and venous thromboembolism, myocardial injury or inflammation resulting in infarction, heart failure, and arrhythmias. Data suggest increased risk of adverse outcomes in pregnant compared with nonpregnant women of reproductive age with COVID-19 infection, including need for intensive care unit admission, mechanical ventilation, and extracorporeal membrane oxygenation utilization. Current statements addressing COVID-19-associated cardiac complications do not include pregnancy complications that may mimic COVID-19 complications such as peripartum cardiomyopathy, spontaneous coronary artery dissection, and preeclampsia. Unique to pregnancy, COVID-19 complications can result in preterm delivery and modify management of the pregnancy. Moreover, pregnancy has often been an exclusion criterion for enrollment in research studies. In this review, we summarize what is known about pregnancy-associated COVID-19 cardiovascular complications.

Keywords: CDC, Centers for Disease Control; COVID-19, coronavirus-2019; ECG, electrocardiogram; ECMO, extracorporeal membrane oxygenation; LV, left ventricular; MI, myocardial injury; PASC, postacute sequelae of SARS-CoV-2 infection; PPCM, peripartum cardiomyopathy; SCAD, spontaneous coronary artery dissection; Tn, cardiac troponin; arrhythmias; cardio-obstetrics; peripartum cardiomyopathy; preeclampsia; thromboembolic disease; vaccine induced thrombocytopenia.

Publication types

  • Review