Abnormal uterine bleeding in women receiving direct oral anticoagulants for the treatment of venous thromboembolism

Vascul Pharmacol. 2017 Aug:93-95:1-5. doi: 10.1016/j.vph.2017.05.001. Epub 2017 May 4.

Abstract

Abnormal uterine bleeding (AUB) is a common complication of anticoagulant therapy in premenopausal women affected with acute venous thromboembolism. AUB impacts quality of life, and can lead to premature cessation of anticoagulation. There is increasing data to suggest that the direct oral anticoagulants when used for the treatment of venous thromboembolism differ in their menstrual bleeding profile. This article aims to review the existing literature regarding the association between AUB and the direct oral anticoagulants and make practical recommendations.

Keywords: Abnormal uterine bleeding; Direct oral anticoagulant; Venous thromboembolism.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anticoagulants / administration & dosage*
  • Anticoagulants / adverse effects*
  • Blood Coagulation / drug effects*
  • Female
  • Humans
  • Menstruation / drug effects*
  • Observational Studies as Topic
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome
  • Uterine Hemorrhage / blood
  • Uterine Hemorrhage / chemically induced*
  • Uterine Hemorrhage / physiopathology
  • Venous Thromboembolism / blood
  • Venous Thromboembolism / diagnosis
  • Venous Thromboembolism / drug therapy*

Substances

  • Anticoagulants