Catastrophic antiphospholipid syndrome presenting with pulmonary hemorrhage: case report

J Thromb Thrombolysis. 2015 Jan;39(1):68-70. doi: 10.1007/s11239-014-1089-y.

Abstract

This is a case report of catastrophic antiphospholipid syndrome (APLS) involving the rare manifestation of pulmonary hemorrhage. This rare variant of APLS is frequently life threatening despite medical therapy. The pathogenesis of pulmonary hemorrhage in catastrophic APLS remains incompletely understood. The optimal approach to managing pulmonary hemorrhage in the setting of catastrophic APLS is still unclear, however this case report demonstrates the success of combination therapy with anticoagulation, corticosteroids and plasma exchange.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Anticoagulants / administration & dosage*
  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / therapy
  • Female
  • Hemorrhage* / etiology
  • Hemorrhage* / therapy
  • Humans
  • Lung Diseases* / etiology
  • Lung Diseases* / therapy
  • Middle Aged
  • Plasma Exchange*

Substances

  • Adrenal Cortex Hormones
  • Anticoagulants