Peri-procedure management of antithrombotic agents and thrombocytopenia for common procedures in oncology: Guidance from the SSC of the ISTH

J Thromb Haemost. 2022 Dec;20(12):3026-3038. doi: 10.1111/jth.15896. Epub 2022 Oct 10.

Abstract

Patients with cancer have an increased risk of thrombosis requiring anticoagulants and/or antiplatelet agents, and they can also encounter thrombocytopenia due to cancer itself or cancer therapies. They often undergo many procedures such as tissue or bone marrow biopsies, placement of central access lines, diagnostic or therapeutic draining procedures, lumbar puncture, and more. Management of antithrombotic agents or thrombocytopenia around the time of these procedures is highly variable. In this document, the Hemostasis and Malignancy Subcommittee of the International Society on Thrombosis and Haemostasis aims to provide useful practice guidance in the management of antithrombotic agents and thrombocytopenia around the time of common procedures in patients with cancer.

Keywords: anticoagulation; antiplatelet; biopsy; cancer; procedure; thrombocytopenia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anticoagulants / adverse effects
  • Fibrinolytic Agents / adverse effects
  • Humans
  • Neoplasms* / complications
  • Neoplasms* / drug therapy
  • Platelet Aggregation Inhibitors / adverse effects
  • Thrombocytopenia* / chemically induced
  • Thrombocytopenia* / diagnosis
  • Thrombocytopenia* / drug therapy
  • Thrombosis* / drug therapy
  • Thrombosis* / etiology
  • Thrombosis* / prevention & control

Substances

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Anticoagulants