Decreased Initial Peak Pain Sensation with Aging: A Psychophysical Study

Ines Daguet; Kayla Bergeron-Vezina; Marie-Philippe Harvey; Marylie Martel; Alexia Coulombe-Leveque; Guillaume Leonard

doi:10.2147/JPR.S257791

Decreased Initial Peak Pain Sensation with Aging: A Psychophysical Study

J Pain Res. 2020 Sep 22:13:2333-2341. doi: 10.2147/JPR.S257791. eCollection 2020.

Authors

Ines Daguet^{1

2}, Kayla Bergeron-Vezina^{1

2}, Marie-Philippe Harvey^{1

2}, Marylie Martel^{1

2}, Alexia Coulombe-Leveque^{1

2

3}, Guillaume Leonard^{1

2

3}

Affiliations

¹ Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada.
³ School of Rehabilitation, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

Abstract

Background and purpose: Aging is associated with an impairment of diverse physiological functions, including nociception. For example, older adults in comparison to young adults, show an overall increase in pain thresholds, reflecting a decline in pain sensitivity and changes in the nociceptive pathways. These results are, however, debated as they were not always replicated depending on the stimulus modality, duration, and location. The aim of the current study was to determine how the temporal evolution of pain intensity during a continuous tonic heat pain test is influenced by aging. More specifically, we wanted to 1) assess the effect of age on initial peak and late-phase pain and 2) determine whether potential age effects depend on the stimulation site.

Participants and methods: 13 young adults (average of 27.9 years old) and 13 older adults (average of 67.5 years old) participated in this study. Experimental heat pain was evoked on an appendicular (forearm) and axial (lower-back) body region, using a thermode (2-minute stimulation at a constant, individually-adjusted temperature). During the nociceptive stimulation, participants used a computerized visual analogue scale to continuously rate their pain.

Results: We show that initial peak (0-30 seconds) pain sensation was significantly lower in older adults compared to young adults, while late-phase (30-120 seconds) pain sensation was similar across the two age groups. These results hold true for both stimulation sites, suggesting the existence of an age effect on both appendicular and axial body regions.

Conclusion: The lower magnitude of initial peak pain observed in older adults, which affects both appendicular and axial body regions, could reflect generalized peripheral or central alterations of the nociceptive system in older adults. These alterations in older adults could have significant clinical impacts, such as an increased vulnerability to injury or an underestimation of the severity of their pain condition.

Keywords: age; aging; elderly; experimental pain; pain; psychophysics.

Grants and funding

This work was supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC). Guillaume Léonard is supported by FRQ-S (Quebec).