fMRI-Informed EEG for brain mapping of imagined lower limb movement: Feasibility of a brain computer interface

Background: EEG and fMRI have contributed greatly to our understanding of brain activity and its link to behaviors by helping to identify both when and where the activity occurs. This is particularly important in the development of brain-computer interfaces (BCIs), where feed forward systems gather data from imagined brain activity and then send that information to an effector. The purpose of this study was to develop and evaluate a computational approach that enables an accurate mapping of spatial brain activity (fMRI) in relation to the temporal receptors (EEG electrodes) associated with imagined lower limb movement.

New method: EEG and fMRI data from 16 healthy, male participants while imagining lower limb movement were used for this purpose. A combined analysis of fMRI data and EEG electrode locations was developed to identify EEG electrodes with a high likelihood of capturing imagined lower limb movement originating from various clusters of brain activity. This novel feature selection tool was used to develop an artificial neural network model to classify right and left lower limb movement.

Results: Results showed that left versus right lower limb imagined movement could be classified with 66.5% accuracy using this approach. Comparison with existing methods: Adopting a purely data-driven approach for feature selection to use in the right/left classification task resulted in the same accuracy (66.6%) but with reduced interpretability.

Conclusions: The developed fMRI-informed EEG approach could pave the way towards improved brain computer interfaces for lower limb movement while also being applicable to other systems where fMRI could be helpful to inform EEG acquisition and processing.