Femur geometry and body composition influence femoral neck stresses: A combined fall simulation and beam modelling approach

J Biomech. 2022 Aug:141:111192. doi: 10.1016/j.jbiomech.2022.111192. Epub 2022 Jun 11.

Abstract

Metrics of femur geometry and body composition have been linked to clinical hip fracture risk. Mechanistic explanations for these relationships have generally focused on femur strength; however, impact loading also modulates fracture risk. We evaluated the potential effects of femur geometry and body composition on femoral neck stresses during lateral impacts. Fifteen female volunteers completed low-energy sideways falls on to the hip. Additionally, participants completed ultrasound and dual-energy x-ray absorptiometry imaging to characterize trochanteric soft tissue thickness (TSTT) over the hip and six metrics of femur geometry, respectively. Subject-specific beam models were developed and utilized to calculate peak femoral neck stress (σNeck), utilizing experimental impact dynamics. Except for femoral neck axis length, all metrics of femur geometry were positively correlated with σNeck (all p < 0.05). Larger/more prominent proximal femurs were associated with increased force over the proximal femur, whereas a wider neck-shaft angle was associated with greater stress generation independent of force (all p < 0.05). Body mass index (BMI) and TSTT were negatively correlated with σNeck (both p < 0.05). Despite strong correlations, these metrics of body composition appear to influence femoral neck stresses through different mechanisms. Increased TSTT was associated with reduced force over the proximal femur, whereas increased BMI was associated with greater resistance to stress generation (both p < 0.05). This study provided novel insights into the mechanistic pathways through which femur geometry and body composition may modulate hip fracture risk. Our findings complement clinical findings and provide one possible explanation for incongruities in the clinical fracture risk and femur strength literature.

Keywords: Dual-energy x-ray absorptiometry; Femur geometry; Hip fracture; Pelvis release; Trochanteric soft tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon / methods
  • Body Composition
  • Bone Density
  • Female
  • Femur
  • Femur Neck* / diagnostic imaging
  • Hip Fractures*
  • Humans