The Impact of Long COVID-19 on Muscle Health

Clin Geriatr Med. 2022 Aug;38(3):545-557. doi: 10.1016/j.cger.2022.03.004. Epub 2022 Mar 21.

Abstract

COVID-19 negatively impacts several organs and systems weeks or months after initial diagnosis. Skeletal muscle can be affected, leading to fatigue, lower mobility, weakness, and poor physical performance. Older adults are at increased risk of developing musculoskeletal symptoms during long COVID. Systemic inflammation, physical inactivity, and poor nutritional status are some of the mechanisms leading to muscle dysfunction in individuals with long COVID. Current evidence suggests that long COVID negatively impacts body composition, muscle function, and quality of life. Muscle mass and function assessments can contribute toward the identification, diagnosis, and management of poor muscle health resulting from long COVID.

Keywords: Aging; Body composition; COVID-19; Muscle function; Muscle mass; Muscle strength; Postacute COVID-19 syndrome; Quality of life.

Publication types

  • Review

MeSH terms

  • Aged
  • COVID-19* / complications
  • Humans
  • Muscle Strength* / physiology
  • Muscle, Skeletal
  • Post-Acute COVID-19 Syndrome
  • Quality of Life