COVID-19 Evidence Alerts
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Current best evidence for clinical care (more info)

Last Updated: April 22, 2021 2:36 PM UTC

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Higher quality studies for clinical attention (more info)

#	Article	Reviewed
1	Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. Sadoff J, Gray G, Vandebosch A, et al. N Engl J Med Reviewed: Apr 22 33882225	Apr 22
2	Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19. Wu L, Zheng Y, Liu J, et al. Aging (Albany NY) Reviewed: Apr 22 33879634	Apr 22
3	The Association of Acute Kidney Injury With Disease Severity and Mortality in COVID-19: A Systematic Review and Meta-Analysis. Menon T, Sharma R, Kataria S, et al. Cureus Reviewed: Apr 22 33880250	Apr 22
4	The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysis. Wang J, Yang W, Chen P, et al. PLoS One Reviewed: Apr 22 33882090	Apr 22
5	Treatment A Phase II Safety and Efficacy Study on Prognosis of Moderate Pneumonia in COVID-19 patients with Regular Intravenous Immunoglobulin Therapy. R S R, Barge VB, Darivenula AK, et al. J Infect Dis Reviewed: Apr 21 33585890	Apr 21
6	Diagnosis Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-throughput Drive-through Community Testing Site in Massachusetts. Pollock NR, Jacobs JR, Tran K, et al. J Clin Microbiol Reviewed: Apr 21 33622768	Apr 21
7	Treatment Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review. Bhowmick S, Dang A, Vallish BN, et al. Drug Saf Reviewed: Apr 21 33864232	Apr 21
8	Diagnosis Efficacy of chest CT scan for COVID-19 diagnosis in a low prevalence and incidence region. Thomas C, Naudin M, Tasu JP, et al. Eur Radiol Reviewed: Apr 20 33871709	Apr 20
9	Prognosis Assessment of activities of daily living in patients post COVID-19: a systematic review. Pizarro-Pennarolli C, Sanchez-Rojas C, Torres-Castro R, et al. PeerJ Reviewed: Apr 20 33868804	Apr 20
10	Manuscript A pre-systematic review on use of masks as protection material for SARS-COV-2 during COVID-19 pandemic. Pires C Int J Clin Pract Reviewed: Apr 20 33848383	Apr 20
11	Manuscript Risk factors and protective measures for healthcare worker infection during highly infectious viral respiratory epidemics: a systematic review and meta-analysis. Tian C, Lovrics O, Vaisman A, et al. Infect Control Hosp Epidemiol Reviewed: Apr 20 33487203	Apr 20
12	Manuscript Non-steroidal anti-inflammatory drugs and susceptibility to COVID-19. Chandan JS, Zemedikun DT, Thayakaran R, et al. Arthritis Rheumatol Reviewed: Apr 20 33185016	Apr 20
13	Manuscript Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients: A Multi-Center Retrospective Study in China. Yuan Y, Sun C, Tang X, et al. Engineering (Beijing) Reviewed: Apr 20 33282444	Apr 20
14	Manuscript Are saliva and deep throat sputum as reliable as common respiratory specimens for SARS-CoV-2 detection? A systematic review and meta-analysis. Khiabani K, Amirzade-Iranaq MH Am J Infect Control Reviewed: Apr 20 33774101	Apr 20
15	Manuscript The link between COVID-19 and VItamin D (VIVID): a systematic review and meta-analysis. Bassatne A, Basbous M, Chakhtoura M, et al. Metabolism Reviewed: Apr 20 33774074	Apr 20
16	Manuscript Clinical Evaluation of Roche SD Biosensor Rapid Antigen Test for SARS-CoV-2 in Municipal Health Service Testing Site, the Netherlands. Igli Z, Velzing J, van Beek J, et al. Emerg Infect Dis Reviewed: Apr 20 33724916	Apr 20
17	Manuscript Progesterone in Addition to Standard of Care Versus Standard of Care Alone in the Treatment of Men Hospitalized with Moderate to Severe COVID-19: A Randomized, Controlled Pilot Trial. Ghandehari S, Matusov Y, Pepkowitz S, et al. Chest Reviewed: Apr 20 33621601	Apr 20
18	Manuscript The protease inhibitor lopinavir, boosted with ritonavir, as treatment for COVID-19: a rapid review. Dorward J, Gbinigie O, Cai T, et al. Antivir Ther Reviewed: Apr 20 33704086	Apr 20
19	Diagnosis Chest CT Diagnosis of COVID-19: Accuracy using CO-RADS and CT-Involvement Scoring. Van Berkel B, Vandevenne J, Coursier K, et al. J Belg Soc Radiol Reviewed: Apr 20 33870081	Apr 20
20	Manuscript The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Molecular Diagnostic Testing. Hanson KE, Caliendo AM, Arias CA, et al. Clin Infect Dis Reviewed: Apr 20 33480973	Apr 20
21	Manuscript Comparison of Associations between Glucocorticoids Treatment and Mortality in COVID-19 Patients and SARS Patients: A Systematic Review and Meta-Analysis. Li J, Liao X, Zhou Y, et al. Shock Reviewed: Apr 20 33555845	Apr 20
22	Manuscript Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos. Babalola OE, Bode CO, Ajayi AA, et al. QJM Reviewed: Apr 20 33599247	Apr 20
23	Manuscript Therapeutic plasma exchange in patients with life-threatening COVID-19: a randomized control clinical trial. Faqihi F, Alharthy A, Abdulaziz S, et al. Int J Antimicrob Agents Reviewed: Apr 20 33838224	Apr 20
24	Treatment Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial. Bennett-Guerrero E, Romeiser JL, Talbot LR, et al. Crit Care Med Reviewed: Apr 20 33870923	Apr 20
25	Manuscript Hydroxychloroquine in mild-to-moderate COVID-19: a placebo-controlled double blind trial. Dubee V, Roy PM, Vielle B, et al. Clin Microbiol Infect Reviewed: Apr 20 33813110	Apr 20
26	Manuscript Community-acquired Pneumonia Severity Assessment Tools in Patients Hospitalized with COVID-19: a Validation and Clinical Applicability Study. Neto FL, Marino LO, Torres A, et al. Clin Microbiol Infect Reviewed: Apr 20 33813111	Apr 20
27	Manuscript Tele-management of home isolated COVID-19 patients via oxygen therapy with non-invasive positive pressure ventilation and physical therapy techniques: A randomized clinical trial. Adly AS, Adly MS, Adly AS J Med Internet Res Reviewed: Apr 20 33819166	Apr 20
28	Primary Prevention Mass Testing With Contact Tracing Compared to Test and Trace for the Effective Suppression of COVID-19 in the United Kingdom: Systematic Review. Mbwogge M JMIRx Med Reviewed: Apr 20 33857269	Apr 20
29	Diagnosis Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis. Tsang NNY, So HC, Ng KY, et al. Lancet Infect Dis Reviewed: Apr 20 33857405	Apr 20
30	Treatment Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline. Chalmers JD, Crichton ML, Goeminne PC, et al. Eur Respir J Reviewed: Apr 20 33692120	Apr 20
31	Manuscript Intermediate vs Standard-dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to ICU: Ninety-day Results from the INSPIRATION Trial. Bikdeli B, Talasaz AH, Rashidi F, et al. Thromb Haemost Reviewed: Apr 20 33865239	Apr 20
32	Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial. Hu K, Guan WJ, Bi Y, et al. Phytomedicine Reviewed: Apr 20 33867046	Apr 20
33	Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & its implications for COVID-19 management in India. Gupta A, Khurana S, Das R, et al. Indian J Med Res Reviewed: Apr 09 33818469	Apr 09
34	Diagnostic accuracy and false-positive rate of chest CT as compared to RT-PCR in coronavirus disease 2019 (COVID-19) pneumonia: A prospective cohort of 612 cases from India and review of literature. Ravikanth R Indian J Radiol Imaging Reviewed: Apr 08 33814777	Apr 08
35	Chloroquine nasal drops in asymptomatic & mild COVID-19: An exploratory randomized clinical trial. Thakar A, Panda S, Sakthivel P, et al. Indian J Med Res Reviewed: Apr 08 33818472	Apr 08
36	Treatment The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial. Mesri M, Esmaeili Saber SS, Godazi M, et al. J Complement Integr Med Reviewed: Apr 06 33787192	Apr 06
37	Manuscript Diagnostic Performance of CO-RADS and the RSNA Classification System in Evaluating COVID-19 at Chest CT: A Meta-Analysis. Kwee RM, Adams HJA, Kwee TC Radiol Cardiothorac Imaging Reviewed: Apr 01 33778660	Apr 01
38	Manuscript Personal protective equipment for reducing the risk of COVID-19 infection among healthcare workers involved in emergency trauma surgery during the pandemic: an umbrella review. Griswold DP, Gempeler A, Kolias A, et al. J Trauma Acute Care Surg Reviewed: Mar 18 33433175	Mar 18
39	Decision-Making Authority During Tele-ICU Care Reduces Mortality and Length of Stay-A Systematic Review and Meta-Analysis. Kalvelage C, Rademacher S, Dohmen S, et al. Crit Care Med Reviewed: Mar 15 33710032	Mar 15
40	Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review. Chagas SCC, Moreira FSM, Barbosa ICF, et al. Sao Paulo Med J Reviewed: Mar 04 33656132	Mar 04
41	Extracorporeal membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: a systematic review and meta-analysis. Zhu Y, Zhang M, Zhang R, et al. Int J Clin Pract Reviewed: Jan 27 33486824	Jan 27
42	The Potential for Cloth Masks to Protect Health Care Clinicians From SARS-CoV-2: A Rapid Review. Daoud AK, Hall JK, Petrick H, et al. Ann Fam Med Reviewed: Jan 13 33431393	Jan 13
43	Manuscript Virtual Geriatric Clinics and the COVID-19 Catalyst: A Rapid Review. Murphy RP, Dennehy KA, Costello MM, et al. Age Ageing Reviewed: Sep 14 32821909	Sep 14

#	Article	Reviewed
1	Clinical Prediction Guide CT-based radiomics for predicting the rapid progression of coronavirus disease 2019 (COVID-19) pneumonia lesions. Zhang B, Ni-Jia-Ti MY, Yan R, et al. Br J Radiol No independent validation cohort Reviewed: Apr 22 33881930	Apr 22
2	Diagnosis Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients. Zonneveld R, Jurriaans S, van Gool T, et al. J Clin Virol Patients were known to have the condition at the beginning of the study Reviewed: Apr 22 33882373	Apr 22
3	Review Hand hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review. Clancy C, Delungahawatta T, Dunne CP J Hosp Infect Weak clinical outcome: compliance with hand hygiene Reviewed: Apr 21 33744382	Apr 21
4	Evidence Based Guideline COVID-19 convalescent plasma: Interim recommendations from the AABB. Cohn CS, Estcourt L, Grossman BJ, et al. Transfusion recommendations from expert panel from American Association of Blood Banks, conducted SR (no databases listed) and measured strength of evidence. Reviewed: Apr 21 33586160	Apr 21
5	Evidence Based Guideline Infection precautions for severe acute respiratory syndrome coronavirus 2 in assisted reproduction centers: dodging an invisible bullet. Sparks AET, Kresowik JD Fertil Steril recommendations from SR, strength of evidence missing Reviewed: Apr 21 33750621	Apr 21
6	Treatment RBD-specific polyclonal F(ab )2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trial. Lopardo G, Belloso WH, Nannini E, et al. EClinicalMedicine Although treatments for COVID change very rapidly, this is still too preliminary as it is not currently available. It is a study to promote increased scalability. Reviewed: Apr 20 33870149	Apr 20
7	Diagnosis Development and performance characteristics evaluation of a new Bioelectric Recognition Assay (BERA) method for rapid Sars-CoV-2 detection in clinical samples. Apostolou T, Kyritsi M, Vontas A, et al. J Virol Methods Patients were known to have the condition at the beginning of the study Reviewed: Apr 20 33872651	Apr 20
8	Diagnosis Comparison of four PCR and two point of care assays used in the laboratory detection of SARS-CoV-2. Kenyeres B, Anosi N, Banyai K, et al. J Virol Methods Patients were known to have the condition at the beginning of the study Reviewed: Apr 20 33872650	Apr 20
9	Diagnosis Diagnostic accuracy of LAMP versus PCR over the course of SARS-CoV-2 infection. Inaba M, Higashimoto Y, Toyama Y, et al. Int J Infect Dis Patients were known to have the condition at the beginning of the study Reviewed: Apr 20 33862213	Apr 20
10	Prognosis Characteristics and outcomes of COVID-19 pneumonia in pregnancy compared with infected nonpregnant women. Vizheh M, Muhidin S, Aghajani F, et al. Int J Gynaecol Obstet No comment provided Reviewed: Apr 20 33829492	Apr 20
11	Review The Utility of Chest CT imaging in suspected or diagnosed COVID-19 Patients - a review of literature. Machnicki S, Patel D, Singh A, et al. Chest Does not report number of studies included after exclusion criteria was applied Reviewed: Apr 20 33861993	Apr 20
12	Diagnosis Convolutional Sparse Support Estimator-Based COVID-19 Recognition From X-Ray Images. Yamac M, Ahishali M, Degerli A, et al. IEEE Trans Neural Netw Learn Syst Patients were known to have the condition at the beginning of the study Reviewed: Apr 20 33872157	Apr 20
13	Clinical Prediction Guide Development and validation of a simple-to-use nomogram to predict the deterioration and survival of patients with COVID-19. Zeng Z, Wu C, Lin Z, et al. BMC Infect Dis No independent validation cohort Reviewed: Apr 20 33863287	Apr 20
14	Treatment Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial. Seet RCS, Quek AML, Ooi DSQ, et al. Int J Infect Dis Less than 80% follow-up Reviewed: Apr 20 33864917	Apr 20
15	Diagnosis CovidXrayNet: Optimizing data augmentation and CNN hyperparameters for improved COVID-19 detection from CXR. Monshi MMA, Poon J, Chung V, et al. Comput Biol Med Patients were known to have the condition at the beginning of the study Reviewed: Apr 20 33866253	Apr 20
16	Evidence Based Guideline ORAL ANTISEPTICS AGAINST CORONAVIRUS: IN VITRO AND CLINICAL EVIDENCE. Mateos Moreno MV, Obrador AM, Marquez VA, et al. J Hosp Infect Strength of evidence for recommendations were not reported Reviewed: Apr 20 33865974	Apr 20
17	Treatment The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19. Rose L, Graham L, Koenecke A, et al. Front Med (Lausanne) Not a randomized controlled trial Reviewed: Apr 20 33869251	Apr 20
18	Prognosis Multisystem Inflammatory Syndrome in Infants <12 months of Age, United States, May 2020-January 2021. Godfred-Cato S, Tsang CA, Giovanni J, et al. Pediatr Infect Dis J No comment provided Reviewed: Apr 20 33872279	Apr 20
19	Etiology A Comparison of Thrombosis and Hemorrhage Rates in Patients With Severe Respiratory Failure Due to Coronavirus Disease 2019 and Influenza Requiring Extracorporeal Membrane Oxygenation. Doyle AJ, Hunt BJ, Sanderson B, et al. Crit Care Med Do not report RRs, HRs, or ORs Reviewed: Apr 19 33861545	Apr 19
20	Treatment Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multicenter International Prospective Registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019 [HOPE-COVID19]). Santoro F, Nunez-Gil IJ, Viana-Llamas MC, et al. Crit Care Med Not a randomized controlled trial Reviewed: Apr 19 33861553	Apr 19
21	Clinical Prediction Guide Clinical Features of Emergency Department Patients from Early COVID-19 Pandemic that Predict SARS-CoV-2 Infection: Machine-learning Approach. Chou EH, Wang CH, Hsieh YL, et al. West J Emerg Med No independent validation cohort Reviewed: Apr 19 33856307	Apr 19
22	Evidence Based Guideline Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report. Mazzone PJ, Gould MK, Arenberg DA, et al. Radiol Imaging Cancer consensus statement with guidelines, expert panel and no SR Reviewed: Apr 19 33778716	Apr 19
23	Prognosis Mother-Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes. Sabharwal V, Bartolome R, Hassan SA, et al. Am J Perinatol No comment provided Reviewed: Apr 17 33853145	Apr 17
24	Economics Economic evaluation of remdesivir for the treatment of severe COVID-19 patients in China under different scenarios. Jiang Y, Cai D, Chen D, et al. Br J Clin Pharmacol Not a randomized controlled trial Reviewed: Apr 17 33855727	Apr 17
25	Treatment Proportion of SARS-CoV - 2 positive tests and Vaccination in VA Community Living Centers. Rudolph JL, Hartronft S, McConeghy K, et al. J Am Geriatr Soc Not a randomized controlled trial Reviewed: Apr 17 33861871	Apr 17
26	Quality Improvement Short-term impact of nursing home SARS-CoV-2 vaccinations on new infections, hospitalizations, and deaths. Mor V, Gutman R, Yang X, et al. J Am Geriatr Soc Not a randomized controlled trial Reviewed: Apr 17 33861873	Apr 17
27	Evidence Based Guideline Mental health interventions following COVID-19 and other coronavirus infections: a systematic review of current recommendations and meta-analysis of randomized controlled trials. Damiano RF, Di Santi T, Beach S, et al. Braz J Psychiatry Strength of evidence for the recommendations were not reported Reviewed: Apr 17 33852690	Apr 17
28	Diagnosis Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers. Padoan A, Bonfante F, Cosma C, et al. Clin Chem Lab Med Patients were known to have the condition at the beginning of the study Reviewed: Apr 17 33855843	Apr 17
29	Clinical Prediction Guide Exploration of prognostic factors for critical COVID-19 patients using a nomogram model. Li J, Wang L, Liu C, et al. Sci Rep No independent validation cohort Reviewed: Apr 17 33854118	Apr 17
30	Prognosis COVID-19: Clinical Presentation and Prognostic Factors of Severe Disease and Mortality in the Oldest-Old Population: A Cohort Study. Galvez-Barron C, Arroyo-Huidobro M, Minarro A, et al. Gerontology No comment provided Reviewed: Apr 17 33853067	Apr 17
31	Diagnosis Comparison of the quantitative DiaSorin Liaison antigen test to RT-PCR for the diagnosis of COVID-19 in symptomatic and asymptomatic outpatients. Lefever S, Indevuyst C, Cuypers L, et al. J Clin Microbiol Patients were known to have the disease at the beginning of the study Reviewed: Apr 16 33849953	Apr 16
32	Prognosis Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. Sallis R, Young DR, Tartof SY, et al. Br J Sports Med No comment provided Reviewed: Apr 16 33849909	Apr 16
33	Treatment Comparison of the antiviral effect of Arbidol and Chloroquine in treating COVID-19. Li M, Yu T, Zhu J, et al. Ann Palliat Med Not a randomized controlled trial Reviewed: Apr 15 33849115	Apr 15
34	Evidence Based Guideline Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks. Supady A, Curtis JR, Abrams D, et al. Lancet Respir Med recommendations provided, no methods Reviewed: Apr 15 33450202	Apr 15
35	Evidence Based Guideline Cancer Screening in the Coronavirus Pandemic Era: Adjusting to a New Situation. Basu P, Alhomoud S, Taghavi K, et al. JCO Glob Oncol recommendations/strategies provided, no methods Reviewed: Apr 15 33784177	Apr 15
36	Etiology The Interplay between the Immune System, the Renin Angiotensin Aldosterone System (RAAS) and RAAS Inhibitors May Modulate the Outcome of COVID-19: A Systematic Review. Naveed H, Elshafeey A, Al-Ali D, et al. J Clin Pharmacol Non-clinical endpoint Reviewed: Apr 14 33635546	Apr 14
37	Review Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy. Chedid M, Waked R, Haddad E, et al. J Infect Public Health Did not search more than one major database Reviewed: Apr 14 33848886	Apr 14
38	Diagnosis Deep CNN-Based CAD System for COVID-19 Detection Using Multiple Lung CT Scans. Ghaderzadeh M, Asadi F, Jafari R, et al. J Med Internet Res Patients were known to have the condition at the beginning of the study Reviewed: Apr 14 33848973	Apr 14
39	Etiology Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study. Aveyard P, Gao M, Lindson N, et al. Lancet Respir Med Risk estimates for outcomes related to use of inhaled corticosteroids did not meet cutpoints Reviewed: Apr 14 33812494	Apr 14
40	Diagnosis EXPRESS: Performance characteristics of five SARS-CoV-2 serological assays: clinical utility in healthcare workers. Heffernan E, Kennedy L, Hannan M, et al. Ann Clin Biochem 100 pre-pandemic samples collected prior to October 2019 were used as true negatives Reviewed: Apr 14 33845592	Apr 14
41	Etiology Risk of COVID-19 Infection Among Chronic Rhinosinusitis Patients Receiving Oral Corticosteroids. Miller LE, Bhattacharyya N Otolaryngol Head Neck Surg Did not report RRs, HRs, or ORs Reviewed: Apr 14 33845681	Apr 14
42	Prognosis Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China. Cheng W, Hornung R, Xu K, et al. Sci Rep No comment provided Reviewed: Apr 14 33846344	Apr 14
43	Diagnosis Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study. Corman VM, Haage VC, Bleicker T, et al. Lancet Microbe Patients were known to have the condition at the beginning of the study Reviewed: Apr 14 33846704	Apr 14
44	Diagnosis Epidemiologic characteristics associated with SARS-CoV-2 antigen-based test results, rRT-PCR cycle threshold values, subgenomic RNA, and viral culture results from university testing. Ford L, Lee C, Pray IW, et al. Clin Infect Dis No independent gold standard Reviewed: Apr 14 33846714	Apr 14
45	Diagnosis Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection. Oh SM, Jeong H, Chang E, et al. J Korean Med Sci Patients were known to have the condition at the beginning of the study Reviewed: Apr 14 33847084	Apr 14
46	Diagnosis Clinical COVID-19 diagnostic methods: Comparison of reverse transcription loop-mediated isothermal amplification (RT-LAMP) and quantitative RT-PCR (qRT-PCR). Kitajima H, Tamura Y, Yoshida H, et al. J Clin Virol Some patients were known to have the condition at the beginning of the study Reviewed: Apr 14 33848785	Apr 14
47	Prognosis SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN). Hall VJ, Foulkes S, Charlett A, et al. Lancet No comment provided Reviewed: Apr 13 33844963	Apr 13
48	Evidence Based Guideline Evidence for changing intimate partner violence safety planning needs as a result of COVID-19: results from phase I of a rapid intervention. Metheny N, Perri M, Velonis A, et al. Public Health Not based on a systematic review Reviewed: Apr 13 33845272	Apr 13
49	Review Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-analysis, and meta-regression. Hariyanto TI, Kurniawan A Nutr Metab Cardiovasc Dis Did not search more than one major database Reviewed: Apr 13 33838992	Apr 13
50	Prognosis Analysis of Risk Factors for Thromboembolic Events in 88 Patients with COVID-19 Pneumonia in Wuhan, China: A Retrospective Descriptive Report. Wang W, Sun Q, Bao Y, et al. Med Sci Monit No comment provided Reviewed: Apr 13 33839733	Apr 13
51	Diagnosis Accuracy of the serological detection of IgG and IgM to SARS-Cov-2: a prospective, cross-sectional study. Pecoraro V, Cassetti T, Meacci M, et al. Eur J Clin Microbiol Infect Dis Patients without the condition were known at the beginning of the study Reviewed: Apr 13 33839972	Apr 13
52	Diagnosis Quantitative pleural line characterization outperforms traditional lung texture ultrasound features in detection of COVID-19. Sultan LR, Chen YT, Cary TW, et al. J Am Coll Emerg Physicians Open Patients were known to have the condition at the beginning of the study Reviewed: Apr 13 33842925	Apr 13
53	Primary Prevention SARS-CoV-2 Neutralizing Antibodies: A Network Meta-Analysis across Vaccines. Rogliani P, Chetta A, Cazzola M, et al. Vaccines (Basel) The analysis isn't according to study design - just the people who received vaccines are included. Reviewed: Apr 13 33807818	Apr 13
54	Diagnosis Diagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19. Lee KK, Doudesis D, Ross DA, et al. BMC Infect Dis Methods poorly reported Reviewed: Apr 12 33823800	Apr 12
55	Diagnosis Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance. Ko JH, Joo EJ, Baek JY, et al. J Microbiol Immunol Infect Patients were known to have the condition at the beginning of the study Reviewed: Apr 11 33836943	Apr 11
56	Diagnosis Clinical validation of the Siemens quantitative SARS-CoV-2 spike IgG assay (sCOVG) reveals improved sensitivity and a good correlation with virus neutralization titers. Irsara C, Egger AE, Prokop W, et al. Clin Chem Lab Med Patients were known to have the condition before the beginning of the study Reviewed: Apr 11 33837679	Apr 11
57	Review Assessment and management of asymptomatic COVID-19 infection: A Systematic Review. Barboza JJ, Chambergo-Michilot D, Velasquez-Sotomayor M, et al. Travel Med Infect Dis Did not search for RCTs Reviewed: Apr 11 33838319	Apr 11
58	Etiology The Effect of Chronic and Inhospital Exposure to Renin-Angiotensin System Inhibitors on the Outcome and Inflammatory State of Coronavirus Disease 2019 Adult Inpatients. Gaspar P, Parreira I, Antunes Meireles P, et al. Int J Hypertens Risk estimates for outcomes do not meet cutpoints Reviewed: Apr 11 33824762	Apr 11
59	Prognosis Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry. Giannis D, Allen S, Tsang J, et al. Blood No comment provided Reviewed: Apr 11 33824972	Apr 11
60	Diagnosis Evaluation of a fully closed real time PCR platform for the detection of SARS-CoV-2 in nasopharyngeal swabs: a pilot study. De Luca C, Gragnano G, Conticelli F, et al. J Clin Pathol Less than 50 patients with and without the condition Reviewed: Apr 11 33837109	Apr 11
61	Evidence Based Guideline COVID-19-Related Occupational Burnout and Moral Distress among Nurses: A Rapid Scoping Review. Sriharan A, West KJ, Almost J, et al. Nurs Leadersh (Tor Ont) Strength of evidence for recommendations were not reported Reviewed: Apr 11 33837685	Apr 11
62	Prognosis The course of subjective and objective chemosensory dysfunction in hospitalized patients with COVID-19: a 6-month follow-up. Bertlich M, Stihl C, Lusebrink E, et al. Eur Arch Otorhinolaryngol No comment provided Reviewed: Apr 11 33837835	Apr 11
63	Diagnosis Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers. Lagerqvist N, Maleki KT, Verner-Carlsson J, et al. Sci Rep Patients were known to have the condition at the beginning of the study Reviewed: Apr 10 33828214	Apr 10
64	Treatment The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review. Zangiabadian M, Nejadghaderi SA, Zahmatkesh MM, et al. Front Endocrinol (Lausanne) Methods poorly reported Reviewed: Apr 10 33815295	Apr 10
65	Diagnosis Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave. Sweeney N, Merrick B, Pedro Galao R, et al. PLoS One Patients were known to have the condition at the beginning of the study Reviewed: Apr 10 33826651	Apr 10
66	Etiology Outcomes of Hospitalized COVID-19 Patients Receiving Renin Angiotensin System Blockers and Calcium Channel Blockers. Choksi TT, Zhang H, Chen T, et al. Am J Nephrol Not standardized data collection; used electronic health records Reviewed: Apr 10 33827074	Apr 10
67	Treatment Early awake proning in critical and severe COVID-19 patients undergoing noninvasive respiratory support: A retrospective multicenter cohort study. Tonelli R, Pisani L, Tabbi L, et al. Pulmonology Not a randomized controlled trial Reviewed: Apr 10 33824084	Apr 10
68	Treatment Pharmacokinetic and Pharmacodynamic Evaluation of Ravulizumab in Adults with Severe Coronavirus Disease 2019. McEneny-King AC, Monteleone JPR, Kazani SD, et al. Infect Dis Ther No clinical outcomes Reviewed: Apr 10 33826106	Apr 10
69	Treatment Percutaneous Dilational Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation. Angel LF, Amoroso NE, Rafeq S, et al. Crit Care Med Not a randomized controlled trial Reviewed: Apr 10 33826583	Apr 10
70	Clinical Prediction Guide EXPRESS: A Composite Risk Model Predicts Disease Progression in Early Stages of COVID-19: a Propensity Score-matched Cohort Study. Xu J, Gao Y, Hu S, et al. Ann Clin Biochem No independent validation cohort Reviewed: Apr 10 33827266	Apr 10
71	Clinical Prediction Guide Prognostic model to identify and quantify risk factors for mortality among hospitalised patients with COVID-19 in the USA. Incerti D, Rizzo S, Li X, et al. BMJ Open No independent validation cohort Reviewed: Apr 10 33827848	Apr 10
72	Prognosis Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19. Sjostrom A, Wersall J, Warnqvist A, et al. Thromb Haemost No comment provided Reviewed: Apr 10 33831964	Apr 10
73	Treatment The effect of azoximer bromide (Polyoxidonium(R)) in patients hospitalized with coronavirus disease (COVID-19): an open-label, multicentre, interventional clinical study. Efimov SV, Matsiyeuskaya NV, Boytsova OV, et al. Drugs Context Not a randomized controlled trial Reviewed: Apr 10 33828607	Apr 10
74	Primary Prevention Similar incidence of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy. Macias J, Gonzalez-Moreno P, Sanchez-Garcia E, et al. PLoS One Not a randomized controlled trial Reviewed: Apr 10 33831011	Apr 10
75	Review Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials. Meza N, Perez-Bracchiglione J, Perez I, et al. Medwave No studies meet their inclusion criteria Reviewed: Apr 10 33830976	Apr 10
76	Treatment Clinical outcomes of using remdesivir in patients with moderate to severe COVID-19: A prospective randomised study. Mahajan L, Singh AP, Gifty Indian J Anaesth Analysis not consistent with design Reviewed: Apr 10 33814589	Apr 10
77	Clinical Prediction Guide Development and Validation of a Clinical Symptom-based Scoring System for Diagnostic Evaluation of COVID-19 Patients Presenting to Outpatient Department in a Pandemic Situation. Bhattacharya A, Ranjan P, Kumar A, et al. Cureus No independent validation cohort Reviewed: Apr 10 33833907	Apr 10
78	Clinical Prediction Guide Classification and analysis of outcome predictors in non-critically ill COVID-19 patients. Venturini S, Orso D, Cugini F, et al. Intern Med J No independent validation cohort Reviewed: Apr 10 33835685	Apr 10
79	Treatment A two-arm, randomized, controlled, multi-centric, open-label phase-2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID-19. Kumar S, De Souza R, Nadkar M, et al. Expert Opin Biol Ther Patients who were randomized, but did not receive the full infusion, were considered unevaluable and the same randomization code was allocated to the next patient enrolled by the study site. Reviewed: Apr 10 33835886	Apr 10
80	Prognosis 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Taquet M, Geddes JR, Husain M, et al. Lancet Psychiatry No comment provided Reviewed: Apr 10 33836148	Apr 10
81	Prognosis Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System. Erben Y, Franco-Mesa C, Gloviczki P, et al. J Vasc Surg Venous Lymphat Disord No comment provided Reviewed: Apr 10 33836287	Apr 10
82	Treatment Effects of Different Dialysis Strategies on Inflammatory Cytokine Profile in Maintenance Hemodialysis Patients with COVID-19: A Randomized Trial. Esposito P, Cipriani L, Verzola D, et al. J Clin Med < 80% follow up, Weak clinical outcome Reviewed: Apr 09 33808205	Apr 09
83	Review Mini-Review Discussing the Reliability and Efficiency of COVID-19 Vaccines. Doroftei B, Ciobica A, Ilie OD, et al. Diagnostics (Basel) No explicit inclusion and exclusion criteria and does not report search results (number of studies) Reviewed: Apr 09 33804914	Apr 09
84	Diagnosis Clinical Evaluation of an Immunochromatographic-Based IgM/IgG Antibody Assay (GenBody COVI040) for Detection of Antibody Seroconversion in Patients with SARS-CoV-2 Infection. Kim D, Lee J, Bal J, et al. Diagnostics (Basel) Patients were known to have the condition at the beginning of the study Reviewed: Apr 09 33802842	Apr 09
85	Diagnosis Higher Accuracy of Lung Ultrasound over Chest X-ray for Early Diagnosis of COVID-19 Pneumonia. Martinez Redondo J, Comas Rodriguez C, Pujol Salud J, et al. Int J Environ Res Public Health No indication that interpretation of the tests were blinded to the results of the gold standard Reviewed: Apr 09 33801638	Apr 09
86	Diagnosis COVID-19 Seroprevalence among Healthcare Workers of a Large COVID-19 Hospital in Rome Reveals Strengths and Limits of Two Different Serological Tests. Vetrugno G, La Milia DI, D'Ambrosio F, et al. Int J Environ Res Public Health All patients did not receive gold standard testing Reviewed: Apr 09 33800721	Apr 09
87	Diagnosis FUSI-CAD: Coronavirus (COVID-19) diagnosis based on the fusion of CNNs and handcrafted features. Ragab DA, Attallah O PeerJ Comput Sci Patients were known to have the condition at the beginning of the study Reviewed: Apr 09 33816957	Apr 09
88	Diagnosis Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative IgG Assays: The Value of Numeric Reporting. Forest SK, Orner EP, Goldstein DY, et al. Arch Pathol Lab Med Gold standard results were known for some patients at the beginning of the study Reviewed: Apr 09 33821952	Apr 09
89	Diagnosis Practicability and analytical performances of the novel VitaPCR(TM) SARS-CoV-2 Assay during the second wave of COVID-19 epidemic in France. Fitoussi F, Dupont R, Tonen-Wolyec S, et al. J Med Virol Methods poorly reported Reviewed: Apr 09 33738829	Apr 09
90	Treatment Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. Emary KRW, Golubchik T, Aley PK, et al. Lancet < 80% follow up, Analysis not consistent with design Reviewed: Apr 08 33798499	Apr 08
91	Review Efficacy and safety of chloroquine and hydroxychloroquine for COVID-19: A comprehensive evidence synthesis of clinical, animal, and in vitro studies. Barzkar F, Ranjbar M, Sioofy-Khojine AB, et al. Med J Islam Repub Iran Content out of date. Important RCT published after search date. Reviewed: Apr 08 33816370	Apr 08
92	Diagnosis Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images. Rahman T, Khandakar A, Qiblawey Y, et al. Comput Biol Med Patients were known to have the disease at the beginning of the study Reviewed: Apr 08 33799220	Apr 08
93	Clinical Prediction Guide Prediction models for clinical severity of COVID-19 patients using multi-center clinical data in Korea. Oh B, Hwangbo S, Jung T, et al. J Med Internet Res No independent validation cohort Reviewed: Apr 08 33822738	Apr 08
94	Treatment ECMO for COVID-19-Associated Severe ARDS in Chile: A Nationwide Incidence and Cohort Study. Diaz RA, Graf J, Zambrano JM, et al. Am J Respir Crit Care Med

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