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COVID-19 Evidence Alerts
from McMaster PLUSTM

Current best evidence for clinical care (more info)

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Prognosis Deniz M, Tezer H Vertical transmission of SARS CoV-2: a systematic review. J Matern Fetal Neonatal Med. 2020 Jul 21:1-8. doi: 10.1080/14767058.2020.1793322.

OBJECTIVE: The aim of this study is to review the current evidence on the vertical transmission of SARS CoV-2.

METHODS: Combination of the following keywords; COVID-19, SARS CoV-2, placenta, vertical transmission, intrauterine infection, breast milk were searched in databases.

RESULTS: In the 50 studies included, 17 newborns testing positive for SARS CoV-2 by RT-PCR were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated. Eight placental tissues testing positive for the virus were reported. Three positive RT-PCR results of test of breast milk have been reported recently. One amniotic fluid testing positive was reported.

CONCLUSION: Possible vertical transmission of SARS CoV-2 has been observed in some studies currently. More RT-PCR tests on amniotic fluid, placenta, breast milk and cord blood are required.

Discipline / Specialty Area Score
Family Medicine (FM)/General Practice (GP)
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Infectious Disease
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Pediatric Neonatology
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